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Datasheet $199.00 – $429.00
Description
Recognizes a protein of 62kDa, which is identified as AKT1. The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKB tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1 (IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s), and the activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin.
Bioinformatics
| Size | 20ug Purified Ab with BSA and Azide at 200ug/ml, 100ug Purified Ab with BSA and Azide at 200ug/ml, 100ug Purified Ab WITHOUT BSA and Azide at 1.0mg/ml |
|---|---|
| Application | IHC, Western Blot |
| Symbol | AKT1 |
| Isotype | kappa, Mouse / IgG2b |
| Species Reactivity | Human. |
| Source | Mouse Monoclonal Antibody |
| Synonyms | AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA |
| Positive Control | PDGF-treated NIH/3T3 cells. HeLa cell lysates. Human pancreas or cervical carcinoma. |
| Cellular Localization | Cytoplasmic and Cell Surface, Nuclear |
| Mol. Weight of Antigen | 62kDa |
| Entrez Gene ID | 207 |
| UniProt | P31749 |
| Clone | AKT1/2552 |
Additional Information
| Storage and Stability | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required. |
|---|---|
| Supplied As | 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Limitations | This antibody is available for research use only and is not approved for use in diagnosis. |
| Warranty | There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product. |
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